Reactome | PLK4 [cytosol]

PLK4 [cytosol]

Stable Identifier

R-CFA-380286

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

PLK4, A0A8I3SAH0

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Canis familiaris)

- Cilium Assembly (Canis familiaris)
  - Anchoring of the basal body to the plasma membrane (Canis familiaris)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Canis familiaris)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
      - mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
    - C2CD3 binds the mother centriole (Canis familiaris)
      - mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
      - mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Canis familiaris)
      - basal body:transition zone proteins [cytosol] (Canis familiaris)
        
        basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Canis familiaris)
        
        basal body:transition zone proteins [cytosol] (Canis familiaris)
        
        basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
    - CP110 and CEP97 dissociate from the centriole (Canis familiaris)
      - basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
    - MARK4 binds ODF2 in the centriole (Canis familiaris)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Canis familiaris)
        
        basal body:transition zone proteins [cytosol] (Canis familiaris)
        
        basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
    - Recruitment of transition zone proteins (Canis familiaris)
      - basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
      - basal body:transition zone proteins [cytosol] (Canis familiaris)
        
        basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
    - The distal appendage proteins recruit TTBK2 (Canis familiaris)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        PLK4 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3SAH0

Gene Names

PLK4

Reference Genes

BioGPS Gene:476087 PLK4

ENSEMBL:ENSCAFG00845026928.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026928.1 PLK4

Monarch:476087 PLK4

NCBI Gene:476087 PLK4

Reference Transcript

RefSeq:XM_533295.4 PLK4

Other Identifiers

476087

CfaAffx.6762.1.S1_at

CfaAffx.6762.1.S1_s_at

GO:0000166

GO:0001741

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005694

GO:0005730

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0007010

GO:0007099

GO:0016301

GO:0016310

GO:0016740

GO:0022414

GO:0030154

GO:0032154

GO:0036211

GO:0042802

GO:0043226

GO:0044782

GO:0046601

GO:0048856

GO:0060271

GO:0060707

GO:0098535

GO:0098536

GO:0120098

GO:0120099

GO:0140096

Participates

as a component of

Inferred From

PLK4 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_533295.2

OpenTargets

ENSG00000142731

Ensembl

ENSCAFT00845047511, ENSCAFG00845026928, ENSCAFP00845037278

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