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active PDGF-AA dimer [extracellular region]
Stable Identifier
R-CFA-380761
Type
Complex
Species
Canis familiaris
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
Exocytosis of platelet alpha granule contents (Canis familiaris)
Platelet alpha granule contents [extracellular region] (Canis familiaris)
PDGF dimer [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Autophosphorylation of PDGF alpha receptors (Canis familiaris)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Downstream signal transduction (Canis familiaris)
Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Activation of Src (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Crk binds to the active PDGF receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
GRB2:SOS1 complex binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Grb7 binds to the active PDGF receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Nck binds to the active PDGF receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PI3-kinase binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PLC-gamma binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
Phosphorylation of PLCgamma by PDGFR (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
SH2 domain of Src binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
SHP2 binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
STAT binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF dimer binds two receptors simultaneously (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF:PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGF-AA clevage by Furin (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFRs bind type I TKI (Canis familiaris)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
PDGFA [extracellular region]
(Canis familiaris)
Participates
as a member of
PDGF dimer [extracellular region] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
as an output of
PDGF-AA clevage by Furin (Canis familiaris)
Inferred From
PDGF A homodimer [extracellular region]
(Homo sapiens)
active PDGF-AA dimer [extracellular region]
(Homo sapiens)
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