Reactome | TPM2 [cytosol]

TPM2 [cytosol]

Stable Identifier

R-CFA-390552

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

TPM2, A0A8I3N002

Locations in the PathwayBrowser

Expand all

Muscle contraction (Canis familiaris)

- Smooth Muscle Contraction (Canis familiaris)
  - ATP Hydrolysis By Myosin (Canis familiaris)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
      - Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
      - Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
  - Calcium Binds Caldesmon (Canis familiaris)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
      - Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Canis familiaris)
      - Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
  - Myosin Binds ATP (Canis familiaris)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
      - Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
      - Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
  - Release Of ADP From Myosin (Canis familiaris)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
      - Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
      - Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
- Striated Muscle Contraction (Canis familiaris)
  - ATP Hydrolysis By Myosin (Canis familiaris)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
        
        Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
        
        Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
  - Calcium Binds Troponin-C (Canis familiaris)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
        
        Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
    - Inactive Sarcomere Protein Complex [cytosol] (Canis familiaris)
      - Thin Filament [cytosol] (Canis familiaris)
        
        Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
  - Myosin Binds ATP (Canis familiaris)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
        
        Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
        
        Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
  - Release Of ADP From Myosin (Canis familiaris)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
        
        Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Canis familiaris)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Canis familiaris)
        
        Tropomyosin [cytosol] (Canis familiaris)
        
        TPM2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N002

Gene Names

TPM2

Reference Genes

BioGPS Gene:481598 TPM2

ENSEMBL:ENSCAFG00845009024.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845009024.1 TPM2

Monarch:481598 TPM2

NCBI Gene:481598 TPM2

Reference Transcript

RefSeq:XM_861479.3 TPM2

Other Identifiers

481598

CfaAffx.4044.1.S1_s_at

GO:0003779

GO:0008092

Participates

as a member of

Tropomyosin [cytosol] (Canis familiaris)

Inferred From

TPM2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_866572.1

OpenTargets

ENSG00000198467

Ensembl

ENSCAFG00845009024, ENSCAFP00845012385, ENSCAFT00845015916