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FBXL5 [cytosol]
Stable Identifier
R-CFA-391295
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
FBXL5, A0A8I3ME81
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
F-box protein [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
Iron uptake and transport (Canis familiaris)
CUL1, SKP1, FBXL5 bind (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
SKP1:CUL1:FBXL5 [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Canis familiaris)
SKP1:CUL1:FBXL5 [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Canis familiaris)
SKP1:CUL1:FBXL5 [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Canis familiaris)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Canis familiaris)
SKP1:CUL1:FBXL5 [cytosol] (Canis familiaris)
FBXL5 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3ME81
Gene Names
FBXL5
Reference Genes
ENSEMBL:ENSCAFG00845001403.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845001403.1 FBXL5
Other Identifiers
479085
Cfa.15199.1.S1_at
Cfa.18553.1.S1_s_at
CfaAffx.23557.1.S1_s_at
GO:0005515
GO:0006879
GO:0016567
GO:0036211
GO:0048471
GO:0055065
GO:0055080
GO:0098771
Participates
as an input of
CUL1, SKP1, FBXL5 bind (Canis familiaris)
as a component of
SKP1:CUL1:FBXL5 [cytosol] (Canis familiaris)
as a member of
F-box protein [cytosol] (Canis familiaris)
Inferred From
FBXL5 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000118564
Ensembl
ENSCAFP00845001939
,
ENSCAFT00845002440
,
ENSCAFG00845001403
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