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CUL2 [cytosol]
Stable Identifier
R-CFA-416982
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CUL2, A0A8I3MEX6
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
VBC complex (with or without LIMD1) [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MEX6
Gene Names
CUL2
Reference Genes
ENSEMBL:ENSCAFG00845002080.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002080.1 CUL2
Other Identifiers
477952
Cfa.19061.1.S1_s_at
Cfa.19886.1.A1_s_at
GO:0005634
GO:0005654
GO:0006511
GO:0016567
GO:0030163
GO:0031462
GO:0031625
GO:0036211
GO:0043226
GO:0140627
GO:0160072
Participates
as a component of
CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
RBX1-CUL2-EloB,C-VHL [cytosol] (Canis familiaris)
Other forms of this molecule
CUL2 [cytosol]
CUL2 [nucleoplasm]
Inferred From
CUL2 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000108094
Ensembl
ENSCAFP00845002960
,
ENSCAFT00845003725
,
ENSCAFG00845002080
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