Reactome | SPTBN5 [cytosol]

SPTBN5 [cytosol]

Stable Identifier

R-CFA-420047

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

SPTBN5, A0A8I3SCP1

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - NCAM signaling for neurite out-growth (Canis familiaris)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
      - Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
      - SOS binds Grb2 bound to pFAK:NCAM1 (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPI-mediated anterograde transport (Canis familiaris)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        COPI vesicle uncoating (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPI-mediated anterograde transport (Canis familiaris)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
      - ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
      - COPI vesicle uncoating (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTBN5 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3SCP1

Gene Names

SPTBN5

Reference Genes

ENSEMBL:ENSCAFG00845030325.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845030325.1 SPTBN5

Other Identifiers

487513

CfaAffx.15467.1.S1_at

CfaAffx.15468.1.S1_s_at

GO:0002046

GO:0003779

GO:0005515

GO:0005737

GO:0005856

GO:0005875

GO:0005929

GO:0007030

GO:0007041

GO:0008092

GO:0019894

GO:0030507

GO:0030863

GO:0032029

GO:0032391

GO:0034452

GO:0042802

GO:0043226

GO:0043621

GO:0045179

GO:0045505

GO:0051015

GO:0097381

Participates

as a member of

Spectrin beta chain [cytosol] (Canis familiaris)

Inferred From

SPTBN5 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000137877

Ensembl

ENSCAFP00845042428, ENSCAFG00845030325, ENSCAFT00845054010

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