Reactome | H3C13 [nucleoplasm]

H3C13 [nucleoplasm]

Stable Identifier

R-CFA-427744

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

Me3K10-HIST2H3A, J9P7X1

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Nuclear Receptors (Canis familiaris)
  - ESR-mediated signaling (Canis familiaris)
    - Estrogen-dependent gene expression (Canis familiaris)
      - ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Canis familiaris)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3C13 [nucleoplasm] (Canis familiaris)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Canis familiaris)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3C13 [nucleoplasm] (Canis familiaris)
      - KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Canis familiaris)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Canis familiaris)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3C13 [nucleoplasm] (Canis familiaris)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase Effectors (Canis familiaris)
      - RHO GTPases activate PKNs (Canis familiaris)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Canis familiaris)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3C13 [nucleoplasm] (Canis familiaris)
        
        PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Canis familiaris)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3C13 [nucleoplasm] (Canis familiaris)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3K9me3 [nucleoplasm] (Canis familiaris)
        
        H3C13 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:J9P7X1

Gene Names

H3C13

Reference Genes

BioGPS Gene:483172 H3C13

ENSEMBL:ENSCAFG00000024443

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000024443 H3C13

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000041871 H3C13

KEGG Gene (Canis lupus familiaris):483172 H3C13

Monarch:483172 H3C13

NCBI Gene:483172 H3C13

Reference Transcript

Participates

as a candidate of

Me3K10-histone H3 [nucleoplasm] (Canis familiaris)

as a member of

H3K9me3 [nucleoplasm] (Canis familiaris)

Other forms of this molecule

H3C13 [nucleoplasm]

phospho-H3C13 [nucleoplasm]

H3C13 [nucleoplasm]

H3C13 [cytosol]

H3C13 [nucleoplasm]

phospho-H3C13 [nucleoplasm]

H3C13 [nucleoplasm]

Inferred From

Me3K10-HIST2H3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

XP_013976105.1, XP_540290.2

OpenTargets

ENSG00000183598