Reactome | phospho-VAV2 [cytosol]

phospho-VAV2 [cytosol]

Stable Identifier

R-CFA-442307

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

p-Y172-VAV2, A0A8I3NEZ8

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by VEGF (Canis familiaris)
    - VEGFA-VEGFR2 Pathway (Canis familiaris)
      - Src kinases phosphorylate VAV (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
      - VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
      - VEGFR2 mediated vascular permeability (Canis familiaris)
        
        PAK1-3 autophosphorylates (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
        
        PAK1-3 dimer disassociates (Canis familiaris)
        
        2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
        
        RAC1 binds PAK1-3 (Canis familiaris)
        
        2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
      - p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)
        
        p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Canis familiaris)
        
        p-VAV family:PIP3 [plasma membrane] (Canis familiaris)
        
        p-VAV family [cytosol] (Canis familiaris)
        
        phospho-VAV2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NEZ8

Gene Names

VAV2

Reference Genes

ENSEMBL:ENSCAFG00845011337.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011337.1 VAV2

Other Identifiers

608060

CfaAffx.30313.1.S1_at

CfaAffx.30313.1.S1_s_at

GO:0001784

GO:0005085

GO:0005154

GO:0005515

GO:0005737

GO:0005886

GO:0007165

GO:0007264

GO:0008361

GO:0016477

GO:0023052

GO:0030031

GO:0030032

GO:0035556

GO:0046872

GO:0048870

GO:0051897

GO:0098772

Participates

as a member of

Other forms of this molecule

VAV2 [cytosol]

Inferred From

p-Y172-VAV2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 172 (in Homo sapiens)

Coordinate

172

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000160293

Ensembl

ENSCAFG00845011337, ENSCAFT00845020123, ENSCAFP00845015773

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