Reactome | RAC1 [cytosol]

RAC1 [cytosol]

Stable Identifier

R-CFA-442615-2

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

P62999

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Regulation of T cell activation by CD28 family (Canis familiaris)
    - Co-stimulation by CD28 (Canis familiaris)
      - CD28 dependent Vav1 pathway (Canis familiaris)
        
        Activation of Rac1 by pVav1 (Canis familiaris)
        
        RAC1:GDP [cytosol] (Canis familiaris)
        
        Homologues of RAC1 [cytosol] (Canis familiaris)
        
        RAC1 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - DAP12 interactions (Canis familiaris)
    - DAP12 signaling (Canis familiaris)
      - Activation of RAC1 by VAV2/3 (Canis familiaris)
        
        RAC1:GDP [cytosol] (Canis familiaris)
        
        Homologues of RAC1 [cytosol] (Canis familiaris)
        
        RAC1 [cytosol] (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - Activation of RAC1 by VAV (Canis familiaris)
        
        RAC1:GDP [cytosol] (Canis familiaris)
        
        Homologues of RAC1 [cytosol] (Canis familiaris)
        
        RAC1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:P62999

Reference Genes

BioGPS Gene:403955

ENSEMBL:ENSCAFG00030017683

KEGG:cfa:403955

Monarch:403955

NCBI Gene:403955

UCSC:P62999

Reference Transcript

RefSeq:NM_001003274.2

Other Identifiers

Cfa.4923.1.A1_s_at

Cfa.4923.1.A2_at

Participates

as a member of

Homologues of RAC1 [cytosol] (Canis familiaris)

Other forms of this molecule

RAC1 [endoplasmic reticulum membrane]

RAC1 [secretory granule membrane]

RAC1 [ficolin-1-rich granule membrane]

GGC-PalmC-RAC1 [plasma membrane]

RAC1 [plasma membrane]

Inferred From

RAC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001003274.1

ENSEMBL

ENSCAFT00845000802, ENSCAFP00845000597

IntEnz

3.6.5.2

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.774	5
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.717	5
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.617	3
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.469	2