Reactome | CETN2 [nucleoplasm]

CETN2 [nucleoplasm]

Stable Identifier

R-CFA-4570490

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

CETN2, A0A8I3PMD5

Locations in the PathwayBrowser

Expand all

DNA Repair (Canis familiaris)

- Nucleotide Excision Repair (Canis familiaris)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
    - DNA Damage Recognition in GG-NER (Canis familiaris)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
      - PARP1 or PARP2 binds DDB2 at GG-NER site (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
      - UV-DDB ubiquitinates XPC (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
      - XPC binds RAD23 and CETN2 (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
      - XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Canis familiaris)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
    - Formation of Incision Complex in GG-NER (Canis familiaris)
      - CHD1L is recruited to GG-NER site (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
      - RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)
        
        Ub,SUMO,K63polyUb:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
      - Recruitment of XPA and release of CAK (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
      - TFIIH binds GG-NER site to form a verification complex (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Canis familiaris)
        
        CETN2 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PMD5

Gene Names

CETN2

Reference Genes

ENSEMBL:ENSCAFG00845021217.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845021217.1 CETN2

Other Identifiers

481078

Cfa.2047.1.A1_at

CfaAffx.29254.1.S1_s_at

GO:0005509

GO:0005815

GO:0005856

GO:0043226

GO:0046872

Participates

as a component of

as an input of

XPC binds RAD23 and CETN2 (Canis familiaris)

Other forms of this molecule

CETN2 [cytosol]

Inferred From

CETN2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000147400

Ensembl

ENSCAFG00845021217, ENSCAFP00845029320, ENSCAFT00845037428

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