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APAF1 [cytosol]
Stable Identifier
R-CFA-50099
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
APAF1, A0A8I3PSY9
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Intrinsic Pathway for Apoptosis (Canis familiaris)
Apoptotic factor-mediated response (Canis familiaris)
Cytochrome c-mediated apoptotic response (Canis familiaris)
Activation of caspases through apoptosome-mediated cleavage (Canis familiaris)
Cleavage of Procaspase-3 by the apoptosome (Canis familiaris)
Apoptosome [cytosol] (Canis familiaris)
APAF1:CYCS [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)
Apoptosome [cytosol] (Canis familiaris)
APAF1:CYCS [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
Formation of apoptosome (Canis familiaris)
CYCS binds to APAF1 (Canis familiaris)
APAF1:ADP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
CYCS:APAF1 binds procaspase-9 (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
Cleavage of Procaspase‑9 to caspase‑9 (Canis familiaris)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Canis familiaris)
APAF1:CYCS [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
Apoptosome [cytosol] (Canis familiaris)
APAF1:CYCS [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
Procaspase 9 forms dimer (Canis familiaris)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
APAF1:CYCS:ATP:CASP9(1-416)dimer [cytosol] (Canis familiaris)
APAF1:CYCS [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
Regulation of the apoptosome activity (Canis familiaris)
APAF1 binds AVEN (Canis familiaris)
APAF1:ADP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
APAF1:AVEN [cytosol] (Canis familiaris)
APAF1:ADP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
APAF1:CYCS binds APIP (Canis familiaris)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
APAF1:CYCS:ATP:APIP [cytosol] (Canis familiaris)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
CASP9 is phosphorylated at T412 (Canis familiaris)
APAF1:ATP:CYCS heptamer:CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS heptamer:p-T412-CASP9 [cytosol] (Canis familiaris)
APAF1:ATP:CYCS [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
XIAP binds CASP9 (Canis familiaris)
Apoptosome [cytosol] (Canis familiaris)
APAF1:CYCS [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
XIAP:apoptosome [cytosol] (Canis familiaris)
Apoptosome [cytosol] (Canis familiaris)
APAF1:CYCS [cytosol] (Canis familiaris)
APAF1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PSY9
Gene Names
APAF1
Reference Genes
ENSEMBL:ENSCAFG00845027232.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845027232.1 APAF1
Reference Transcript
RefSeq:XM_003432034.3 APAF1
RefSeq:XM_014119284.1 APAF1
RefSeq:XM_005629260.2 APAF1
Other Identifiers
482620
Cfa.2404.1.A1_at
CfaAffx.10785.1.S1_at
GO:0000166
GO:0001843
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006915
GO:0007420
GO:0008656
GO:0012501
GO:0023052
GO:0030900
GO:0032991
GO:0042802
GO:0042981
GO:0043226
GO:0043293
GO:0043531
GO:0048856
GO:0051402
GO:0070059
GO:0097190
GO:0098772
GO:1902510
GO:2001235
Participates
as a component of
APAF1:ADP [cytosol] (Canis familiaris)
APAF1:ATP [cytosol] (Canis familiaris)
APAF1:CYCS [cytosol] (Canis familiaris)
Other forms of this molecule
APAF1 [secretory granule lumen]
APAF1 [extracellular region]
APAF1 [ficolin-1-rich granule lumen]
Inferred From
APAF1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_013974759.1
,
XP_003432082.1
,
XP_005629317.1
OpenTargets
ENSG00000120868
Ensembl
ENSCAFP00845037757
,
ENSCAFT00845048127
,
ENSCAFG00845027232
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