Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
BRCA1 [nucleoplasm]
Stable Identifier
R-CFA-50949
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
BRCA1, A0A8I3N406
Locations in the PathwayBrowser
Expand all
DNA Repair (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
BAP1 binds BRCA1:BARD1 heterodimer (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1:BAP1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
BAP1 disrupts the BRCA1:BARD1 heterodimer (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1:BAP1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
BRCA1 forms a heterodimer with BARD1 (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 heterodimer autoubiquitinates (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
Formation of BRCA1-A complex at DNA DSBs (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Canis familiaris)
BRCA1-A Complex [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Canis familiaris)
BRCA1-A Complex [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Metalloprotease DUBs (Canis familiaris)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)
BRCA1-A Complex:Histone H2A [nucleoplasm] (Canis familiaris)
BRCA1-A Complex [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
BRCA1-A Complex:K63polyUb-histone H2A [nucleoplasm] (Canis familiaris)
BRCA1-A Complex [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
BRCA1 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N406
Gene Names
BRCA1
Reference Genes
BioGPS Gene:403437 BRCA1
ENSEMBL:ENSCAFG00845006070.1
Monarch:403437 BRCA1
NCBI Gene:403437 BRCA1
UCSC:A0A8I3N406 BRCA1
Reference Transcript
RefSeq:XM_038674917.1 BRCA1
RefSeq:XM_038674916.1 BRCA1
RefSeq:XM_038674915.1 BRCA1
Other Identifiers
403437
Cfa.140.1.S1_s_at
GO:0000152
GO:0000228
GO:0000724
GO:0000793
GO:0000794
GO:0000800
GO:0000976
GO:0001673
GO:0001741
GO:0002039
GO:0003677
GO:0003684
GO:0003713
GO:0003723
GO:0003824
GO:0004842
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005886
GO:0006281
GO:0006301
GO:0006302
GO:0006310
GO:0006325
GO:0006355
GO:0006357
GO:0006629
GO:0006631
GO:0006633
GO:0006974
GO:0007059
GO:0007095
GO:0007098
GO:0008270
GO:0008630
GO:0010212
GO:0010575
GO:0010628
GO:0016567
GO:0016604
GO:0016740
GO:0019899
GO:0030308
GO:0031436
GO:0031625
GO:0032991
GO:0033147
GO:0042802
GO:0043009
GO:0044027
GO:0044818
GO:0045717
GO:0045739
GO:0045766
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0051726
GO:0051865
GO:0060816
GO:0070013
GO:0070063
GO:0070531
GO:0070532
GO:0070533
GO:0071356
GO:0071479
GO:0071681
GO:0085020
GO:0140096
GO:1902042
GO:1990391
GO:1990904
GO:2000378
Participates
as an output of
BAP1 disrupts the BRCA1:BARD1 heterodimer (Canis familiaris)
as an input of
BRCA1 forms a heterodimer with BARD1 (Canis familiaris)
as a component of
BRCA1:BARD1 [nucleoplasm] (Canis familiaris)
Other forms of this molecule
phospho-BRCA1 [nucleoplasm]
phospho-BRCA1 [nucleoplasm]
BRCA1 [nucleoplasm]
phospho-BRCA1 [nucleoplasm]
phospho-BRCA1 [nucleoplasm]
Inferred From
BRCA1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_038530843.1
,
XP_038530845.1
,
XP_038530844.1
ENSEMBL
ENSCAFP00845008432
,
ENSCAFT00845010804
,
ENSCAFG00845006070
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text