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VCP hexamer [cytosol]
Stable Identifier
R-CFA-5362364
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Canis familiaris)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)
Deglycosylation complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
Neddylation (Canis familiaris)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 6
VCP [cytosol]
(Canis familiaris)
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
Deglycosylation complex [endoplasmic reticulum membrane] (Canis familiaris)
Inferred From
VCP hexamer [cytosol]
(Homo sapiens)
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