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ERCC6 [nucleoplasm]
Stable Identifier
R-CFA-54429
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
ERCC6, A0A8I3PAF3
Locations in the PathwayBrowser
Expand all
DNA Repair (Canis familiaris)
Nucleotide Excision Repair (Canis familiaris)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
Dual incision in TC-NER (Canis familiaris)
3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
TC-NER incision complex [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
ERCC5 and RPA bind TC-NER site (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
Formation of TC-NER Pre-Incision Complex (Canis familiaris)
ERCC6 binds stalled RNA Pol II (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
Epigenetic regulation of gene expression (Canis familiaris)
Positive epigenetic regulation of rRNA expression (Canis familiaris)
B-WICH complex positively regulates rRNA expression (Canis familiaris)
B-WICH complex binds rDNA promoter (Canis familiaris)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Canis familiaris)
B-WICH [nucleoplasm] (Canis familiaris)
ERCC6 dimer [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
ERCC6 dimer [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
B-WICH recruits histone acetyltransferases (Canis familiaris)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Canis familiaris)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Canis familiaris)
B-WICH [nucleoplasm] (Canis familiaris)
ERCC6 dimer [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Canis familiaris)
B-WICH [nucleoplasm] (Canis familiaris)
ERCC6 dimer [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Canis familiaris)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Canis familiaris)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Canis familiaris)
B-WICH [nucleoplasm] (Canis familiaris)
ERCC6 dimer [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
RNA Polymerase I Transcription (Canis familiaris)
RNA Polymerase I Promoter Clearance (Canis familiaris)
RNA Polymerase I Transcription Initiation (Canis familiaris)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Canis familiaris)
ERCC6 dimer [nucleoplasm] (Canis familiaris)
ERCC6 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PAF3
Gene Names
ERCC6
Reference Genes
BioGPS Gene:477747 ERCC6
ENSEMBL:ENSCAFG00845020981.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845020981.1 ERCC6
KEGG Gene (Canis lupus familiaris):477747 ERCC6
Monarch:477747 ERCC6
NCBI Gene:477747 ERCC6
Reference Transcript
RefSeq:XM_534944.4 ERCC6
Other Identifiers
477747
Cfa.1909.1.A1_s_at
CfaAffx.10874.1.S1_at
GO:0000012
GO:0000077
GO:0000166
GO:0000303
GO:0003677
GO:0003682
GO:0003824
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006281
GO:0006283
GO:0006284
GO:0006290
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006362
GO:0006974
GO:0006979
GO:0007254
GO:0008023
GO:0008094
GO:0008630
GO:0009411
GO:0009636
GO:0010165
GO:0010224
GO:0010332
GO:0012501
GO:0022008
GO:0023052
GO:0030154
GO:0030182
GO:0030296
GO:0031175
GO:0032784
GO:0032786
GO:0035264
GO:0043226
GO:0045494
GO:0045739
GO:0045945
GO:0048856
GO:0060261
GO:0090734
GO:0097680
GO:0098772
GO:0110016
GO:0140097
GO:0140657
GO:0140658
GO:1905168
GO:2001033
Participates
as a component of
ERCC6 dimer [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
as an input of
ERCC6 binds stalled RNA Pol II (Canis familiaris)
Other forms of this molecule
ERCC6 [nucleoplasm]
Inferred From
ERCC6 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_534944.2
OpenTargets
ENSG00000225830
Ensembl
ENSCAFP00845029280
,
ENSCAFG00845020981
,
ENSCAFT00845037377
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