Reactome | PAXIP1 [nucleoplasm]

PAXIP1 [nucleoplasm]

Stable Identifier

R-CFA-5619395

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

PAXIP1, A0A8I3RX86

Locations in the PathwayBrowser

Expand all

DNA Repair (Canis familiaris)

- DNA Double-Strand Break Repair (Canis familiaris)
  - Nonhomologous End-Joining (NHEJ) (Canis familiaris)
    - Activated ATM phosphorylates DCLRE1C (Canis familiaris)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Canis familiaris)
        
        PAXIP1 [nucleoplasm] (Canis familiaris)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Canis familiaris)
        
        PAXIP1 [nucleoplasm] (Canis familiaris)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Canis familiaris)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Canis familiaris)
        
        PAXIP1 [nucleoplasm] (Canis familiaris)
      - PAXIP1 [nucleoplasm] (Canis familiaris)
    - TP53BP1 recruits DCLRE1C to ATM (Canis familiaris)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Canis familiaris)
        
        PAXIP1 [nucleoplasm] (Canis familiaris)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] (Canis familiaris)
        
        PAXIP1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RX86

Gene Names

PAXIP1

Reference Genes

ENSEMBL:ENSCAFG00845012859.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845012859.1 PAXIP1

Other Identifiers

482813

CfaAffx.8530.1.S1_s_at

GO:0001570

GO:0002376

GO:0005634

GO:0005654

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006974

GO:0010212

GO:0023052

GO:0030154

GO:0030330

GO:0031398

GO:0035097

GO:0036211

GO:0043226

GO:0043542

GO:0044666

GO:0045830

GO:0048304

GO:0048856

GO:0048870

GO:0060261

GO:0060612

GO:0060717

GO:1902749

Participates

as an input of

as a component of

Inferred From

PAXIP1 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000157212

Ensembl

ENSCAFG00845012859, ENSCAFT00845022910, ENSCAFP00845017960