Reactome | CYFIP1 [cytosol]

CYFIP1 [cytosol]

Stable Identifier

R-CFA-5672575

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

CYFIP1, A0A8I3NVZ2

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
      - ABL phosphorylates WAVEs (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
      - Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
      - p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by VEGF (Canis familiaris)
    - VEGFA-VEGFR2 Pathway (Canis familiaris)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase Effectors (Canis familiaris)
      - RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        ABL phosphorylates WAVEs (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
    - RHO GTPase cycle (Canis familiaris)
      - RAC1 GTPase cycle (Canis familiaris)
        
        RAC1 binds effectors at the plasma membrane (Canis familiaris)
        
        RAC1 effectors [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
        
        RAC1 effectors [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1,CYFIP2 [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
      - RAC2 GTPase cycle (Canis familiaris)
        
        RAC2 binds effectors at the plasma membrane (Canis familiaris)
        
        RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
        
        WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Canis familiaris)
        
        RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
        
        WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
      - RAC3 GTPase cycle (Canis familiaris)
        
        RAC3 binds effectors at the plasma membrane (Canis familiaris)
        
        RAC3 effectors [cytosol] (Canis familiaris)
        
        WAVE1 Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        RAC3:GTP:RAC3 effectors [plasma membrane] (Canis familiaris)
        
        RAC3 effectors [cytosol] (Canis familiaris)
        
        WAVE1 Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
      - RHOG GTPase cycle (Canis familiaris)
        
        RHOG binds effectors at the plasma membrane (Canis familiaris)
        
        RHOG plasma membrane effectors [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Canis familiaris)
        
        RHOG plasma membrane effectors [cytosol] (Canis familiaris)
        
        CYFIP1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NVZ2

Gene Names

CYFIP1

Reference Genes

ENSEMBL:ENSCAFG00845015950.1

UCSC:A0A8I3NVZ2 CYFIP1

Other Identifiers

479001

Cfa.351.1.A1_at

CfaAffx.15273.1.S1_s_at

GO:0005737

GO:0010592

GO:0016601

GO:0030833

GO:0031209

GO:0031267

GO:0048675

GO:0050877

GO:0050890

GO:2000601

Participates

as a member of

as a candidate of

RHOG plasma membrane effectors [cytosol] (Canis familiaris)

as a component of

Other forms of this molecule

CYFIP1 [specific granule lumen]

CYFIP1 [secretory granule lumen]

CYFIP1 [extracellular region]

CYFIP1 [tertiary granule lumen]

Inferred From

CYFIP1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFT00845028555, ENSCAFP00845022466, ENSCAFG00845015950

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