Reactome | XRCC2 [nucleoplasm]

XRCC2 [nucleoplasm]

Stable Identifier

R-CFA-5685302

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

XRCC2, A0A8I3RWP7

Locations in the PathwayBrowser

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DNA Repair (Canis familiaris)

- DNA Double-Strand Break Repair (Canis familiaris)
  - Homology Directed Repair (Canis familiaris)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
      - HDR through Homologous Recombination (HRR) (Canis familiaris)
        
        D-loop extension by DNA polymerases (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Homologous DNA Pairing and Strand Exchange (Canis familiaris)
        
        CX3 complex binds D-loop structures (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Canis familiaris)
        
        BCDX2 complex formation (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex stabilizes RAD51 filament (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Resolution of D-Loop Structures (Canis familiaris)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Canis familiaris)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Canis familiaris)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        FIGNL1 binds RAD51 (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        XRCC2 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RWP7

Gene Names

XRCC2

Reference Genes

BioGPS Gene:475548 XRCC2

ENSEMBL:ENSCAFG00845011729.1

KEGG:cfa:475548 XRCC2

Monarch:475548 XRCC2

NCBI Gene:475548 XRCC2

UCSC:A0A8I3RWP7 XRCC2

Reference Transcript

Other Identifiers

475548

CfaAffx.8359.1.S1_at

GO:0000278

GO:0000400

GO:0000724

GO:0001701

GO:0001756

GO:0003677

GO:0005524

GO:0005654

GO:0005657

GO:0005813

GO:0005815

GO:0006281

GO:0006310

GO:0006974

GO:0007098

GO:0010165

GO:0010332

GO:0022008

GO:0030154

GO:0033063

GO:0035264

GO:0042148

GO:0043524

GO:0048856

GO:0050769

GO:0140664

GO:2000269

Participates

as an input of

BCDX2 complex formation (Canis familiaris)

as a component of

BCDX2 complex [nucleoplasm] (Canis familiaris)

Inferred From

XRCC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_532771.3, XP_038415712.1, XP_038545479.1

ENSEMBL

ENSCAFT00845020803, ENSCAFG00845011729, ENSCAFP00845016325

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