Reactome | IRS2 [cytosol]

IRS2 [cytosol]

Stable Identifier

R-CFA-57528

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

F1Q219

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Erythropoietin (Canis familiaris)
  - EPOR binds EPOR agonists (Canis familiaris)
    - EPOR agonists:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
      - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
    - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
      - IRS2 [cytosol] (Canis familiaris)
  - Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
    - EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - PI3K bound to EPOR [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
    - JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
  - Erythropoietin activates RAS (Canis familiaris)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by Insulin receptor (Canis familiaris)
    - Insulin receptor signalling cascade (Canis familiaris)
      - IRS activation (Canis familiaris)
        
        Binding of IRS to insulin receptor (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
        
        IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
        
        Phosphorylation of IRS (Canis familiaris)
        
        IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
    - IGF1R signaling cascade (Canis familiaris)
      - IRS-related events triggered by IGF1R (Canis familiaris)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)
        
        IRS2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1Q219

Reference Genes

ENSEMBL:ENSCAFG00000006058

Participates

as a member of

RET interactors [cytosol] (Canis familiaris)

as an input of

as a component of

Other forms of this molecule

IRS2 [plasma membrane]

phospho-p-Y-IRS2 [cytosol]

phospho-p-Y-IRS2 [plasma membrane]

Inferred From

IRS1,2 [cytosol] (Homo sapiens)

IRS2 [cytosol] (Homo sapiens)

Cross References

VGNC

42099

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