Reactome | AQR [nucleoplasm]

AQR [nucleoplasm]

Stable Identifier

R-CFA-6781960

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

AQR, A0A8I3QBP2

Locations in the PathwayBrowser

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DNA Repair (Canis familiaris)

- Nucleotide Excision Repair (Canis familiaris)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
    - Dual incision in TC-NER (Canis familiaris)
      - 3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
        
        TC-NER incision complex [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
        
        TC-NER incision complex [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
        
        TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
      - ERCC5 and RPA bind TC-NER site (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
    - Formation of TC-NER Pre-Incision Complex (Canis familiaris)
      - Assembly of the pre-incision complex in TC-NER (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
      - UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
        
        TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        XAB2 complex [nucleoplasm] (Canis familiaris)
        
        AQR [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3QBP2

Gene Names

AQR

Reference Genes

ENSEMBL:ENSCAFG00845031121.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845031121.1 AQR

Other Identifiers

478251

Cfa.1188.1.S1_at

CfaAffx.13302.1.S1_s_at

CfaAffx.13313.1.S1_s_at

GO:0000398

GO:0003723

GO:0003727

GO:0003824

GO:0004386

GO:0005634

GO:0005654

GO:0005681

GO:0006397

GO:0008380

GO:0016071

GO:0034458

GO:0043226

GO:0071007

GO:0071013

GO:0140098

GO:0140657

Participates

as a component of

Inferred From

AQR [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000021776

Ensembl

ENSCAFP00845043522, ENSCAFT00845055332, ENSCAFG00845031121

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