Reactome | NDUFS8 [mitochondrial matrix]

NDUFS8 [mitochondrial matrix]

Stable Identifier

R-CFA-6788526

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

mitochondrial matrix

Synonyms

NDUFS8, A0A8I3N8W7

Locations in the PathwayBrowser

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Metabolism (Canis familiaris)

- Aerobic respiration and respiratory electron transport (Canis familiaris)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Canis familiaris)
    - Respiratory electron transport (Canis familiaris)
      - Complex I biogenesis (Canis familiaris)
        
        IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        Intermediate 2 [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        NDUF subunits bind to form the IP subcomplex (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        NUBPL transfers 4Fe-4S to Complex I subunits (Canis familiaris)
        
        NDUF subunits [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        NDUF:4Fe-4S subunits [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Canis familiaris)
        
        815kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        980kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        815kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Canis familiaris)
        
        980kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        815kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 [mitochondrial inner membrane] (Canis familiaris)
        
        IP subcomplex [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
        
        Complex I [mitochondrial inner membrane] (Canis familiaris)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Canis familiaris)
        
        Complex I [mitochondrial inner membrane] (Canis familiaris)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Canis familiaris)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)
        
        NDUFS8 [mitochondrial matrix] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N8W7

Gene Names

NDUFS8

Reference Genes

ENSEMBL:ENSCAFG00845008677.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008677.1 NDUFS8

Reference Transcript

RefSeq:XM_005631068.2 NDUFS8

Other Identifiers

610413

Cfa.11633.1.A1_at

Cfa.12499.1.A1_s_at

GO:0003824

GO:0016020

GO:0016491

GO:0016651

GO:0051539

Participates

as a member of

NDUF subunits [mitochondrial matrix] (Canis familiaris)

as a component of

NDUFS8:2x4Fe-4S [mitochondrial matrix] (Canis familiaris)

Inferred From

NDUFS8 [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

XP_005631125.1

OpenTargets

ENSG00000110717

Ensembl

ENSCAFG00845008677, ENSCAFT00845015271, ENSCAFP00845011858

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