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HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]
Stable Identifier
R-CFA-6806977
Type
Complex
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by MET (Canis familiaris)
MET Receptor Activation (Canis familiaris)
MET dimers autophosphorylate (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
Activated MET binds GAB1 (Canis familiaris)
HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
Activated MET binds GAB1 and GRB2 (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET phosphorylates GAB1 (Canis familiaris)
HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET activates PTPN11 (Canis familiaris)
GAB1 binds PTPN11 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET activates RAS signaling (Canis familiaris)
Activated MET binds RANBP9 and SOS1 (Canis familiaris)
HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
Activated MET recruits GRB2-1:SOS1 (Canis familiaris)
HGF:p-4Y MET dimer:MUC20 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET binds RANBP10 (Canis familiaris)
HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET binds SHC1-2 (Canis familiaris)
HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET phosphorylates SHC1-2 (Canis familiaris)
HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MUC20 binds MET and inhibits GRB2 binding (Canis familiaris)
HGF:p-4Y MET dimer:MUC20 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
SHC1-2 bound to MET recruits GRB2:SOS1 (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET activates STAT3 (Canis familiaris)
MET phosphorylates STAT3 (Canis familiaris)
HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
STAT3 binds activated MET receptor (Canis familiaris)
HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET promotes cell motility (Canis familiaris)
MET activates PTK2 signaling (Canis familiaris)
MET phosphorylates PTK2 (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
PTK2 autophosphorylates (Canis familiaris)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
PTK2 binds activated MET (Canis familiaris)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
SRC phosphorylates PTK2 (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
p-Y397-PTK2 binds SRC (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET activates RAP1 and RAC1 (Canis familiaris)
CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
DOCK7 activates RAC1 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
GAB1 recruits CRK,CRKL to MET (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
RAPGEF1 activates RAP1 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
RAPGEF1 binds CRK,CRKL (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET interacts with TNS proteins (Canis familiaris)
MET binds TNS3 (Canis familiaris)
HGF:p-4Y-MET dimer:TNS3 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET binds TNS4 (Canis familiaris)
HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET receptor recycling (Canis familiaris)
GGA3 associates with activated MET receptor (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
Negative regulation of MET activity (Canis familiaris)
CBL binds MET (Canis familiaris)
HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
CBL monoubiquitinates activated MET (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
MET phosphorylates CBL (Canis familiaris)
HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
PTPRJ dephosphorylates MET (Canis familiaris)
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(Canis familiaris)
Participates
as an output of
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)
MET phosphorylates STAT3 (Canis familiaris)
MET dimers autophosphorylate (Canis familiaris)
as an input of
PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)
PTPRJ dephosphorylates MET (Canis familiaris)
PTK2 binds activated MET (Canis familiaris)
MET binds TNS4 (Canis familiaris)
MET binds TNS3 (Canis familiaris)
MET binds RANBP10 (Canis familiaris)
MUC20 binds MET and inhibits GRB2 binding (Canis familiaris)
Activated MET binds GAB1 and GRB2 (Canis familiaris)
Activated MET binds GAB1 (Canis familiaris)
STAT3 binds activated MET receptor (Canis familiaris)
MET binds SHC1-2 (Canis familiaris)
Activated MET recruits GRB2-1:SOS1 (Canis familiaris)
Activated MET binds RANBP9 and SOS1 (Canis familiaris)
as a component of
HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Canis familiaris)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:TNS3 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-4Y MET dimer:MUC20 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
as a member of
HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Canis familiaris)
Inferred From
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]
(Homo sapiens)
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