Reactome | Desmosome [plasma membrane]

Desmosome [plasma membrane]

Stable Identifier

R-CFA-6814388

Type

Complex

Species

Canis familiaris

Compartment

plasma membrane

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Keratinization (Canis familiaris)
  - Formation of the cornified envelope (Canis familiaris)
    - CASP14 cleaves filaggrin (Canis familiaris)
      - Late cornified envelope [plasma membrane] (Canis familiaris)
        
        Cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
      - Mature cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        No FGN-Cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-late cornified envelope [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
    - CDSN binds the cornified envelope (Canis familiaris)
      - Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
      - Cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
    - Filaggrin binds Keratin tonofilament:Desmosome (Canis familiaris)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
      - Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
    - Fillagrin and keratin intermediate filaments polymerize forming a network (Canis familiaris)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
      - FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
    - Lamellar bodies bind the early cornified envelope (Canis familiaris)
      - Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
      - Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
    - PERP binds desmosomes (Canis familiaris)
      - Desmosome [plasma membrane] (Canis familiaris)
      - Desmosome:PERP [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
    - Plasma membrane resorption (Canis familiaris)
      - Mature cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        No FGN-Cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-late cornified envelope [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
  - Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)
    - Desmosome [plasma membrane] (Canis familiaris)
    - Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
      - Desmosome [plasma membrane] (Canis familiaris)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an input of

as a component of

Inferred From

Desmosome [plasma membrane] (Homo sapiens)