Reactome | PKP2 [plasma membrane]

PKP2 [plasma membrane]

Stable Identifier

R-CFA-6814393

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

PKP2, A0A8I3NZ03

Locations in the PathwayBrowser

Expand all

Developmental Biology (Canis familiaris)

- Keratinization (Canis familiaris)
  - Formation of the cornified envelope (Canis familiaris)
    - CASP14 cleaves filaggrin (Canis familiaris)
      - Late cornified envelope [plasma membrane] (Canis familiaris)
        
        Cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
      - Mature cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        No FGN-Cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-late cornified envelope [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
    - CDSN binds the cornified envelope (Canis familiaris)
      - Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
      - Cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
    - Filaggrin binds Keratin tonofilament:Desmosome (Canis familiaris)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
      - Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
    - Fillagrin and keratin intermediate filaments polymerize forming a network (Canis familiaris)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
      - FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
    - Lamellar bodies bind the early cornified envelope (Canis familiaris)
      - Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
      - Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
    - PERP binds desmosomes (Canis familiaris)
      - Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
      - Desmosome:PERP [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
    - Plasma membrane resorption (Canis familiaris)
      - Mature cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        No FGN-Cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-late cornified envelope [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
  - Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)
    - Desmosome [plasma membrane] (Canis familiaris)
      - Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)
    - Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
      - Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP2 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NZ03

Gene Names

PKP2

Reference Genes

ENSEMBL:ENSCAFG00845016150.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016150.1 PKP2

Other Identifiers

486613

CfaAffx.16402.1.S1_s_at

GO:0002159

GO:0003012

GO:0003013

GO:0005080

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005886

GO:0005911

GO:0007010

GO:0007155

GO:0010810

GO:0014704

GO:0019215

GO:0023052

GO:0030054

GO:0030057

GO:0030154

GO:0034330

GO:0043226

GO:0045110

GO:0045294

GO:0048496

GO:0048856

GO:0055010

GO:0060090

GO:0072659

GO:0086002

GO:0086005

GO:0086019

GO:0086073

GO:0086091

GO:0098609

GO:0098911

GO:1900024

Participates

as a member of

Plakophilins [plasma membrane] (Canis familiaris)

Other forms of this molecule

PKP2 [cornified envelope]

Inferred From

PKP2 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000057294

Ensembl

ENSCAFT00845028835, ENSCAFG00845016150, ENSCAFP00845022690

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