Reactome | PKP4 [plasma membrane]

PKP4 [plasma membrane]

Stable Identifier

R-CFA-6814401

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

PKP4, A0A8I3Q1A4

Locations in the PathwayBrowser

Expand all

Developmental Biology (Canis familiaris)

- Keratinization (Canis familiaris)
  - Formation of the cornified envelope (Canis familiaris)
    - CASP14 cleaves filaggrin (Canis familiaris)
      - Late cornified envelope [plasma membrane] (Canis familiaris)
        
        Cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
      - Mature cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        No FGN-Cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-late cornified envelope [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
    - CDSN binds the cornified envelope (Canis familiaris)
      - Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
      - Cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
    - Filaggrin binds Keratin tonofilament:Desmosome (Canis familiaris)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
      - Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
    - Fillagrin and keratin intermediate filaments polymerize forming a network (Canis familiaris)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
      - FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
    - Lamellar bodies bind the early cornified envelope (Canis familiaris)
      - Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
      - Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
    - PERP binds desmosomes (Canis familiaris)
      - Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
      - Desmosome:PERP [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
    - Plasma membrane resorption (Canis familiaris)
      - Mature cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        No FGN-Cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-late cornified envelope [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
  - Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)
    - Desmosome [plasma membrane] (Canis familiaris)
      - Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)
    - Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
      - Desmosome [plasma membrane] (Canis familiaris)
        
        Plakophilins [plasma membrane] (Canis familiaris)
        
        PKP4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q1A4

Gene Names

PKP4

Reference Genes

ENSEMBL:ENSCAFG00845026973.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026973.1 PKP4

Other Identifiers

478759

Cfa.16902.1.S1_s_at

Cfa.20050.1.S1_s_at

Cfa.3365.1.A1_at

Cfa.3365.1.A1_s_at

CfaAffx.14770.1.S1_at

CfaAffx.14770.1.S1_s_at

GO:0000910

GO:0000922

GO:0005515

GO:0005737

GO:0005856

GO:0005886

GO:0005911

GO:0007043

GO:0007155

GO:0009898

GO:0014069

GO:0030054

GO:0030057

GO:0030496

GO:0032467

GO:0034330

GO:0043226

GO:0044291

GO:0048471

GO:0051233

GO:0072686

GO:0098609

Participates

as a candidate of

as a member of

Plakophilins [plasma membrane] (Canis familiaris)

Other forms of this molecule

PKP4 [cornified envelope]

Inferred From

PKP4 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000144283

Ensembl

ENSCAFG00845026973, ENSCAFT00845047555, ENSCAFP00845037316

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