Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
MCM2 [nucleoplasm]
Stable Identifier
R-CFA-68557
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
MCM2, J9P937
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
Activation of ATR in response to replication stress (Canis familiaris)
Activation of claspin (Canis familiaris)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Loading of claspin onto DNA during replication origin firing (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1/S Transition (Canis familiaris)
Activation of the pre-replicative complex (Canis familiaris)
Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
DNA polymerase alpha:primase binds at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
DNA polymerase epsilon binds at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Canis familiaris)
MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
Mcm4,6,7 trimer forms and associates with the replication fork (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
DNA Replication (Canis familiaris)
DNA Replication Pre-Initiation (Canis familiaris)
Activation of the pre-replicative complex (Canis familiaris)
Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Cdt1 is displaced from the pre-replicative complex. (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
DNA polymerase alpha:primase binds at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
DNA polymerase epsilon binds at the origin (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
active pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Canis familiaris)
MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Assembly of the pre-replicative complex (Canis familiaris)
Formation of MCM2-7 complex (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
Mcm4,6,7 trimer forms and associates with the replication fork (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
pre-replicative complex [nucleoplasm] (Canis familiaris)
MCM2-7 [nucleoplasm] (Canis familiaris)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
MCM2 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:J9P937
Gene Names
MCM2
Reference Genes
ENSEMBL:ENSCAFG00000004052
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000004052 MCM2
Other Identifiers
484622
CfaAffx.7006.1.S1_s_at
GO:0000166
GO:0000228
GO:0000785
GO:0003674
GO:0003677
GO:0003678
GO:0003688
GO:0004386
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005664
GO:0005694
GO:0005737
GO:0006259
GO:0006260
GO:0006268
GO:0006270
GO:0006334
GO:0006915
GO:0007049
GO:0008150
GO:0008219
GO:0009058
GO:0016787
GO:0016887
GO:0019899
GO:0022607
GO:0032508
GO:0032991
GO:0034641
GO:0042393
GO:0042555
GO:0043167
GO:0043226
GO:0046872
GO:0048856
GO:0051276
GO:0065003
GO:0071353
GO:0090102
GO:1905775
Participates
as an output of
Mcm4,6,7 trimer forms and associates with the replication fork (Canis familiaris)
as an input of
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Canis familiaris)
as a component of
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Canis familiaris)
Inferred From
MCM2 [nucleoplasm]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000073111
Ensembl
ENSCAFT00000045532
,
ENSCAFG00000004052
,
ENSCAFP00000042269
VGNC
43081
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
