Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate

Stable Identifier
Reaction [transition]
Canis familiaris
Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
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This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also:

Catalyst Activity

pyruvate carboxylase activity of pyruvate carboxylase holoenzyme [mitochondrial matrix]

This event is regulated
Positively by

The mitochondrial pyruvate dehydrogenase (PDH) complex (lipo-PDH) irreversibly decarboxylates pyruvate to acetyl CoA, thereby serving to oxidatively remove lactate, which is in equilibrium with pyruvate, and to link glycolysis in the cytosol to the tricarboxylic acid cycle in the mitochondria matrix. Pyruvate Dehydrogenase Kinase (PDK) in the mitochondrial matrix catalyzes the phosphorylation of serine residues of the E1 alpha subunit of the PDH complex, inactivating it. Acetyl CoA positively regulates this reaction (Bao et al. 2004).

Inferred From
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