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RIPK2 [cytosol]
Stable Identifier
R-CFA-706483
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
Ub-209-RIPK2, A0A8I3PFI5
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
NOD1/2 Signaling Pathway (Canis familiaris)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
RIP2 is K63 polyubiquitinated (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
TAK1 is activated (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ovarian tumor domain proteases (Canis familiaris)
TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
RIPK2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PFI5
Gene Names
RIPK2
Reference Genes
ENSEMBL:ENSCAFG00845018948.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018948.1 RIPK2
Other Identifiers
477936
Cfa.20490.1.S1_at
CfaAffx.14149.1.S1_s_at
GO:0000166
GO:0001961
GO:0002250
GO:0002376
GO:0002827
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005737
GO:0006468
GO:0006914
GO:0006950
GO:0007155
GO:0007249
GO:0007254
GO:0008152
GO:0010033
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0023052
GO:0030154
GO:0031349
GO:0031663
GO:0032103
GO:0032722
GO:0032729
GO:0032743
GO:0032755
GO:0032760
GO:0032874
GO:0033080
GO:0033092
GO:0034142
GO:0035739
GO:0036211
GO:0042098
GO:0042981
GO:0043065
GO:0043123
GO:0043330
GO:0045087
GO:0045627
GO:0046330
GO:0048856
GO:0050830
GO:0050852
GO:0051403
GO:0060907
GO:0070371
GO:0070374
GO:0070427
GO:0070431
GO:0070555
GO:0070671
GO:0070673
GO:0070887
GO:0071222
GO:0071223
GO:0071224
GO:0071225
GO:0098542
GO:0098792
GO:0140096
GO:1904417
GO:2000563
Participates
as a component of
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Canis familiaris)
Other forms of this molecule
RIPK2 [cytosol]
Inferred From
Ub-209-RIPK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at 209 (in Homo sapiens)
Coordinate
209
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
OpenTargets
ENSG00000104312
Ensembl
ENSCAFT00845033465
,
ENSCAFG00845018948
,
ENSCAFP00845026197
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