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RPS27A(77-156) [cytosol]
Stable Identifier
R-CFA-72363
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A8I3NUE4
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Canis familiaris)
Nonsense-Mediated Decay (NMD) (Canis familiaris)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Protein ubiquitination (Canis familiaris)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Canis familiaris)
UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Translation (Canis familiaris)
Eukaryotic Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Canis familiaris)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
Translation initiation complex formation (Canis familiaris)
Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Formation of a pool of free 40S subunits (Canis familiaris)
Release of 40S and 60S subunits from the 80S ribosome (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
40S:eIF3:eIF1A [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Formation of the ternary complex, and subsequently, the 43S complex (Canis familiaris)
Formation of the 43S pre-initiation complex (Canis familiaris)
40S:eIF3:eIF1A [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
GTP hydrolysis and joining of the 60S ribosomal subunit (Canis familiaris)
The 60S subunit joins the translation initiation complex (Canis familiaris)
40S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
eIF2:GTP is hydrolyzed, eIFs are released (Canis familiaris)
40S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
eIF5B:GTP is hydrolyzed and released (Canis familiaris)
80S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Ribosomal scanning and start codon recognition (Canis familiaris)
Ribosomal scanning (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Start codon recognition (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
L13a-mediated translational silencing of Ceruloplasmin expression (Canis familiaris)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
Ribosome-associated quality control (Canis familiaris)
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (Canis familiaris)
ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (Canis familiaris)
ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Canis familiaris)
80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Canis familiaris)
RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide (Canis familiaris)
K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
K63polyUb-80S ribosome [cytosol] (Canis familiaris)
K63polyUb-40S ribosomal subunit [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] (Canis familiaris)
K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
K63polyUb-80S ribosome [cytosol] (Canis familiaris)
K63polyUb-40S ribosomal subunit [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Canis familiaris)
K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
K63polyUb-80S ribosome [cytosol] (Canis familiaris)
K63polyUb-40S ribosomal subunit [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Canis familiaris)
80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Canis familiaris)
80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Canis familiaris)
80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
SRP-dependent cotranslational protein targeting to membrane (Canis familiaris)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)
SRP:polypeptide+signal:ribosome [cytosol] (Canis familiaris)
ribosome:mRNA:polypeptide+signal [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
ribosome:mRNA:polypeptide+signal [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS27A(77-156) [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NUE4
Reference Genes
ENSEMBL:ENSCAFG00845015591.1
UCSC:A0A8I3NUE4
Other Identifiers
GO:0003735
GO:0005198
GO:0005515
GO:0005634
GO:0005737
GO:0016567
GO:0019941
GO:0031386
GO:0031625
Participates
as a component of
K63polyUb-40S ribosomal subunit [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
as an output of
UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Canis familiaris)
Other forms of this molecule
RPS27A(77-156) [nucleoplasm]
Ub-33-RPS27A(1-76) [mitochondrial outer membrane]
Ub-6-RPS27A(1-76) [mitochondrial outer membrane]
Ub-11-RPS27A(1-76) [mitochondrial outer membrane]
Ub-48-RPS27A(1-76) [mitochondrial outer membrane]
Ub-29-RPS27A(1-76) [mitochondrial outer membrane]
Ub-27-RPS27A(1-76) [mitochondrial outer membrane]
N6-glycyl-L-lysine-RPS27A(1-76) [cytosol]
phospho-adenylatedlG76-RPS27A(1-76) [nucleoplasm]
RPS27A [cytosol]
phospho-adenylatedlG76-RPS27A(1-76) [cytosol]
RPS27A(1-76) [endosome membrane]
Ub-63-RPS27A(1-76) [mitochondrial outer membrane]
Ub-29-RPS27A(1-76) [cytosol]
Ub-6-RPS27A(1-76) [cytosol]
Ub-27-RPS27A(1-76) [cytosol]
Ub-33-RPS27A(1-76) [cytosol]
RPS27A(1-76) [endoplasmic reticulum membrane]
Ub-27-RPS27A(1-76) [nucleoplasm]
Ub-29-RPS27A(1-76) [nucleoplasm]
Ub-33-RPS27A(1-76) [nucleoplasm]
Ub-11-RPS27A(1-76) [nucleoplasm]
Ub-11-RPS27A(1-76) [cytosol]
RPS27A(1-76) [nucleoplasm]
Ub-48-RPS27A(1-76) [nucleoplasm]
Ub-63-RPS27A(1-76) [nucleoplasm]
Ub-6-RPS27A(1-76) [nucleoplasm]
Ub-48-RPS27A(1-76) [cytosol]
RPS27A(1-76) [cytosol]
Ub-63-RPS27A(1-76) [cytosol]
Inferred From
RPS27A(77-156) [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845021875
,
ENSCAFT00845027793
,
ENSCAFG00845015591
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