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EIF4G1 [cytosol]
Stable Identifier
R-CFA-72584
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
F1PNF3
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
ISG15 antiviral mechanism (Canis familiaris)
Competitive inhibition of translation initiation by ISGylated 4EHP (Canis familiaris)
EIF4F [cytosol] (Canis familiaris)
EIF4G [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
eIF4F:mRNA [cytosol] (Canis familiaris)
EIF4F [cytosol] (Canis familiaris)
EIF4G [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Metabolism of RNA (Canis familiaris)
Deadenylation-dependent mRNA decay (Canis familiaris)
Deadenylation of mRNA (Canis familiaris)
PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)
Partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Translatable mRNA Complex [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
ZCCHC6, ZCCHC11 are mRNA uridyltransferases (Canis familiaris)
Partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Nonsense-Mediated Decay (NMD) (Canis familiaris)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
mRNA Cleaved by SMG6 [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
mRNA Cleaved by SMG6 [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Regulation of mRNA stability by proteins that bind AU-rich elements (Canis familiaris)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Canis familiaris)
AUF1 (hnRNP D0) is ubiquitinylated (Canis familiaris)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
AUF1 binds translation and heat shock proteins (Canis familiaris)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Translation (Canis familiaris)
Eukaryotic Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Canis familiaris)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
Cap-bound mRNA is activated by helicases (Canis familiaris)
eIF4F:mRNP [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Formation of the cap-binding eIF4F complex (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Translation initiation complex formation (Canis familiaris)
Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Ribosomal scanning and start codon recognition (Canis familiaris)
Ribosomal scanning (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
L13a-mediated translational silencing of Ceruloplasmin expression (Canis familiaris)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
MTOR signalling (Canis familiaris)
mTORC1-mediated signalling (Canis familiaris)
Phosphorylation and activation of eIF4G by activated S6K1 (Canis familiaris)
EIF4G1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1PNF3
Reference Genes
ENSEMBL:ENSCAFG00000012687
Participates
as an input of
AUF1 binds translation and heat shock proteins (Canis familiaris)
Phosphorylation and activation of eIF4G by activated S6K1 (Canis familiaris)
Formation of the cap-binding eIF4F complex (Canis familiaris)
as a component of
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Canis familiaris)
mRNA Cleaved by SMG6 [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Canis familiaris)
Uridylated partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
Partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
Translatable mRNA Complex [cytosol] (Canis familiaris)
eIF4F [cytosol] (Canis familiaris)
as a member of
EIF4G [cytosol] (Canis familiaris)
as an output of
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)
Other forms of this molecule
phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol]
Inferred From
EIF4G1 [cytosol]
(Homo sapiens)
Cross References
VGNC
40289
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