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CALM1:4xCa2+ [cytosol]
Stable Identifier
R-CFA-74294
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Calcineurin activates NFAT (Canis familiaris)
Calcineurin binds NFATC1,2,3 (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Calcineurin:p-NFATC1,2,3 [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
NFAT:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Smooth Muscle Contraction (Canis familiaris)
MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
MYLK:Ca2+:CALM1 [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
MYLK:Ca2+:CALM1 [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
Activation of NMDA receptors and postsynaptic events (Canis familiaris)
Post NMDA receptor activation events (Canis familiaris)
Activation of RAC1 downstream of NMDARs (Canis familiaris)
CAMK1 binds calmodulin (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
CAMK1:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
CaMKK autophosphorylates in the cytosol (Canis familiaris)
CaMKK:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
p-CaMKK:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The phototransduction cascade (Canis familiaris)
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
CALM1:Ca2+ binds CNG channel (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:Ca2+:CNG channel [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
DAG and IP3 signaling (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
Cam-PDE 1 activation (Canis familiaris)
Calmodulin activates Cam-PDE 1 (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
GRK2 binds CALM1:4Ca2+ (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
GRK2:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
PKA-mediated phosphorylation of CREB (Canis familiaris)
PKA activation (Canis familiaris)
Adenylate cyclase produces cAMP (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAF activation (Canis familiaris)
Phosphorylation of RAF (Canis familiaris)
RAF activating kinases [plasma membrane] (Canis familiaris)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
RAS processing (Canis familiaris)
ARL2:GTP bind PDE6D on KRAS4B (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Calmodulin dissociates KRAS4B from the plasma membrane (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
KRAS4B recycles to the plasma membrane (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B binds calmodulin (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
Ca-dependent events (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
Cam-PDE 1 activation (Canis familiaris)
Calmodulin activates Cam-PDE 1 (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
GRK2 binds CALM1:4Ca2+ (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
GRK2:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
PKA-mediated phosphorylation of CREB (Canis familiaris)
PKA activation (Canis familiaris)
Adenylate cyclase produces cAMP (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases activate PAKs (Canis familiaris)
MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
MYLK:Ca2+:CALM1 [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Active calmodulin binds CAMK2 (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
CAMK2:CaM [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Autophosphorylation and activation of CAMK2 (Canis familiaris)
CAMK2:CaM [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
p-T286 CAMK2:CaM [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
NFATC1:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
p-T286 CAMK2:CaM [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)
NFATC1:CaN:CaM [cytosol] (Canis familiaris)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Canis familiaris)
CALM1:4xCa2+ [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 4
Ca2+ [cytosol]
CALM2 [cytosol]
(Canis familiaris)
Participates
as an input of
CALM1:Ca2+ binds CNG channel (Canis familiaris)
Activation of Calcineurin (Canis familiaris)
Active calmodulin binds CAMK2 (Canis familiaris)
MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)
GRK2 binds CALM1:4Ca2+ (Canis familiaris)
CAMK1 binds calmodulin (Canis familiaris)
S-Farn-Me KRAS4B binds calmodulin (Canis familiaris)
Calcineurin binds NFATC1,2,3 (Canis familiaris)
as a component of
CALM1:Ca2+:CNG channel [plasma membrane] (Canis familiaris)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Canis familiaris)
p-T286 CAMK2:CaM [cytosol] (Canis familiaris)
CAMK2:CaM [cytosol] (Canis familiaris)
MYLK:Ca2+:CALM1 [cytosol] (Canis familiaris)
GRK2:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
p-CaMKK:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CaMKK:CALM1:4xCa2+ [cytosol] (Canis familiaris)
CAMK1:CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] (Canis familiaris)
S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
PPP3CA,B:Calmodulin [cytosol] (Canis familiaris)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Canis familiaris)
as an output of
Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)
KRAS4B recycles to the plasma membrane (Canis familiaris)
This entity regulates
Positively
Phosphorylation of Smooth Muscle Myosin Light Chains
(Canis familiaris)
Calmodulin activates Cam-PDE 1
(Canis familiaris)
Adenylate cyclase produces cAMP
(Canis familiaris)
Inferred From
CALM1:4xCa2+ [cytosol]
(Homo sapiens)
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