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INS [extracellular region]
Stable Identifier
R-CFA-74672
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
4xHC-INS(90-110), P01321
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Canis familiaris)
Peptide hormone metabolism (Canis familiaris)
Synthesis, secretion, and deacylation of Ghrelin (Canis familiaris)
Acyl Ghrelin and C-Ghrelin are secreted (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)
Activated SRC,LCK,EGFR,INSR [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Autophosphorylation of insulin receptor (Canis familiaris)
Insulin:Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin binds the insulin receptor (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin:Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
Binding of SHC1 to insulin receptor (Canis familiaris)
GRB10:INSR [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Dissociation of p-Y427-SHC1 from insulin receptor (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
IRS activation (Canis familiaris)
Binding of IRS to insulin receptor (Canis familiaris)
GRB10:INSR [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Dissociation of IRS-P from insulin receptor (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Phosphorylation of IRS (Canis familiaris)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Phosphorylation of SHC1 (Canis familiaris)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Signal attenuation (Canis familiaris)
Binding of Grb10 to the insulin receptor (Canis familiaris)
GRB10:INSR [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
Internalisation of the insulin receptor (Canis familiaris)
Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
Insulin [extracellular region] (Canis familiaris)
INS [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:P01321
Gene Names
INS
Reference Genes
BioGPS Gene:483665 INS
ENSEMBL:ENSCAFG00845011141
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000010092.6 INS
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805009726 INS
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011141.1 INS
KEGG Gene (Canis lupus familiaris):483665 INS
Monarch:483665 INS
NCBI Gene:483665 INS
Reference Transcript
RefSeq:NM_001130093.1 INS
Other Identifiers
483665
Cfa.18796.1.S1_s_at
GO:0000278
GO:0001819
GO:0002020
GO:0002376
GO:0002674
GO:0003013
GO:0005158
GO:0005159
GO:0005179
GO:0005576
GO:0005615
GO:0005975
GO:0006091
GO:0006520
GO:0006521
GO:0006629
GO:0006953
GO:0006954
GO:0007186
GO:0008284
GO:0008286
GO:0010628
GO:0010629
GO:0010750
GO:0023052
GO:0030154
GO:0030163
GO:0032880
GO:0034330
GO:0038060
GO:0042060
GO:0042177
GO:0042311
GO:0042593
GO:0042802
GO:0043410
GO:0045725
GO:0045818
GO:0045821
GO:0045840
GO:0045861
GO:0045922
GO:0046326
GO:0046628
GO:0046631
GO:0048018
GO:0048856
GO:0050708
GO:0050709
GO:0050995
GO:0051247
GO:0051897
GO:0055085
GO:0055086
GO:0055089
GO:0060266
GO:0060267
GO:0072659
GO:0098542
GO:0098772
GO:0140014
GO:1900182
GO:1901135
GO:1902952
GO:1903076
GO:1903427
GO:1990535
GO:2000252
Participates
as a component of
Insulin [extracellular region] (Canis familiaris)
Other forms of this molecule
INS [Golgi lumen]
INS [secretory granule lumen]
INS [endoplasmic reticulum lumen]
INS [endoplasmic reticulum lumen]
INS [endoplasmic reticulum-Golgi intermediate compartment membrane]
INS [transport vesicle]
INS [Golgi membrane]
INS [endosome lumen]
INS [endosome lumen]
INS [extracellular region]
Inferred From
4xHC-INS(90-110) [extracellular region]
(Homo sapiens)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 95 and 100 (in Homo sapiens)
Coordinate
95
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 109 and 43 (in Homo sapiens)
Coordinate
109
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 96 and 31 (in Homo sapiens)
Coordinate
96
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_001123565.1
OpenTargets
ENSG00000254647
Ensembl
ENSCAFP00845015468
,
ENSCAFG00845011141
,
ENSCAFT00845019762
VGNC
97204
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