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NBN [nucleoplasm]
Stable Identifier
R-CFA-75163
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
NBN, A0A8I3PAJ3
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular Senescence (Canis familiaris)
DNA Damage/Telomere Stress Induced Senescence (Canis familiaris)
KAT5 acetylates ATM at DNA DSBs (Canis familiaris)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
KAT5 acetylates ATM at shortened telomeres (Canis familiaris)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN activates ATM (Canis familiaris)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN bound to shortened telomeres activates ATM (Canis familiaris)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN complex binds DNA double strand breaks (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN complex binds shortened telomeres (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN complex bound to DNA ends recruits ATM (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN complex bound to shortened telomeres recruits ATM (Canis familiaris)
Shortened telomere:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
DNA Repair (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
ATM phosphorylates NBN (Canis familiaris)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Sensing of DNA Double Strand Breaks (Canis familiaris)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
KAT5 acetylates ATM at DNA DSBs (Canis familiaris)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
KPNA2 translocates NBN to the nucleus (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN activates ATM (Canis familiaris)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN complex binds DNA double strand breaks (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN complex bound to DNA ends recruits ATM (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Homology Directed Repair (Canis familiaris)
HDR through MMEJ (alt-NHEJ) (Canis familiaris)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
LIG3 ligates remaining SSBs in MMEJ (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN complex binds RBBP8 (Canis familiaris)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
MRN recruits LIG3:XRCC1 to MMEJ sites (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Canis familiaris)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Canis familiaris)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Canis familiaris)
MRN [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PAJ3
Gene Names
NBN
Reference Genes
ENSEMBL:ENSCAFG00845019442.1
UCSC:A0A8I3PAJ3 NBN
Other Identifiers
611315
Cfa.861.1.S1_at
Cfa.861.2.S1_s_at
CfaAffx.14194.1.S1_s_at
GO:0000077
GO:0000723
GO:0000724
GO:0000729
GO:0000781
GO:0001701
GO:0001832
GO:0002376
GO:0003677
GO:0003684
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005730
GO:0005794
GO:0006281
GO:0006302
GO:0006310
GO:0006325
GO:0007095
GO:0007405
GO:0016605
GO:0022414
GO:0030870
GO:0031848
GO:0031860
GO:0031954
GO:0032200
GO:0032206
GO:0032508
GO:0035861
GO:0042393
GO:0042405
GO:0043226
GO:0043247
GO:0043539
GO:0045190
GO:0048856
GO:0050877
GO:0050885
GO:0051321
GO:0060090
GO:0062176
GO:0070533
GO:0090656
GO:0090737
GO:0097193
GO:0097681
GO:0098772
GO:0110025
GO:0140031
GO:0140297
GO:0140463
GO:1904354
GO:1990166
Participates
as an input of
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Canis familiaris)
as a component of
MRN [nucleoplasm] (Canis familiaris)
as an output of
KPNA2 translocates NBN to the nucleus (Canis familiaris)
Other forms of this molecule
NBN [cytosol]
phospho-NBN [nucleoplasm]
Inferred From
NBN [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFT00845034448
,
ENSCAFP00845026980
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