Reactome | MRN [nucleoplasm]

MRN [nucleoplasm]

Stable Identifier

R-CFA-75164

Type

Complex

Species

Canis familiaris

Compartment

nucleoplasm

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

MRE11 [nucleoplasm] (Canis familiaris)
NBN [nucleoplasm] (Canis familiaris)
RAD50 [nucleoplasm] (Canis familiaris)

Participates

as an output of

LIG3 ligates remaining SSBs in MMEJ (Canis familiaris)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Canis familiaris)

as a component of

Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Canis familiaris)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Canis familiaris)
Shortened telomere:MRN [nucleoplasm] (Canis familiaris)
DNA DSBs:MRN [nucleoplasm] (Canis familiaris)

as an input of

MRN complex binds shortened telomeres (Canis familiaris)
MRN complex binds DNA double strand breaks (Canis familiaris)

Inferred From

MRN [nucleoplasm] (Homo sapiens)