Reactome | IFNA5 [extracellular region]

IFNA5 [extracellular region]

Stable Identifier

R-CFA-877338-4

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

P81255

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Interferon Signaling (Canis familiaris)
    - Interferon alpha/beta signaling (Canis familiaris)
      - Activation of JAK kinases (Canis familiaris)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
      - Formation of p-STAT1 homodimer (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
      - IFN alpha/beta binds to IFNAR2 (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
      - Phosphorylation of INFAR1 by TYK2 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
      - Phosphorylation of STAT2 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
      - Recruitment of IFNAR1 (Canis familiaris)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
      - Recruitment of STAT2 to p-IFNAR1 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
      - Regulation of IFNA/IFNB signaling (Canis familiaris)
        
        Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
      - Release of p-STAT2:p-STAT1 dimer (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Canis familiaris)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Canis familiaris)
        
        IFNA [extracellular region] (Canis familiaris)
        
        Homologues of IFNA5 [extracellular region] (Canis familiaris)
        
        IFNA5 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:P81255

Reference Genes

BioGPS Gene:100685213

BioGPS Gene:100688005

BioGPS Gene:100688084

ENSEMBL:ENSCAFG00000051832

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000051832.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000054523.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000055920.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000056067.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030003837.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030003866.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040010698.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040010712.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040010740.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805019007

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024287

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024341

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024377

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024413

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024470

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024513

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024542

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024606

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016109.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016171.1

KEGG Gene (Canis lupus familiaris):100685213

KEGG Gene (Canis lupus familiaris):100688005

KEGG Gene (Canis lupus familiaris):100688084

Monarch:100685213

Monarch:100688005

Monarch:100688084

NCBI Gene:100685213

NCBI Gene:100688005

NCBI Gene:100688084

Reference Transcript

Other Identifiers

100682977

100685213

100688005

100688084

GO:0005126

GO:0005576

GO:0006952

Participates

as a member of

Homologues of IFNA5 [extracellular region] (Canis familiaris)

Other forms of this molecule

IFNA6 [extracellular region]

IFNA2 [extracellular region]

IFNA1 [extracellular region]

Inferred From

IFNA5 [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_003431605.1, XP_003431692.2, XP_003431693.1, XP_003431691.1

Ensembl

ENSCAFT00845028654, ENSCAFP00845022551, ENSCAFT00845028742, ENSCAFP00845022623, ENSCAFG00845016109, ENSCAFG00845016171

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