Reactome | FEM1A [cytosol]

FEM1A [cytosol]

Stable Identifier

R-CFA-8863141

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

FEM1A, A0A5F4CAV7

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL2-box protein [cytosol] (Canis familiaris)
        
        FEM1A [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A5F4CAV7

Gene Names

FEM1A

Reference Genes

BioGPS Gene:485032 FEM1A

ENSEMBL:ENSCAFG00000048123

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000048123 FEM1A

KEGG Gene (Canis lupus familiaris):485032 FEM1A

Monarch:485032 FEM1A

NCBI Gene:485032 FEM1A

Reference Transcript

RefSeq:XM_542150.5 FEM1A

Participates

as a member of

CUL2-box protein [cytosol] (Canis familiaris)

Inferred From

FEM1A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_542150.2

OpenTargets

ENSG00000141965

VGNC

108244