Reactome | KLHL5 [cytosol]

KLHL5 [cytosol]

Stable Identifier

R-CFA-8863223

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

KLHL5, A0A8I3RTS7

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Class I MHC mediated antigen processing & presentation (Canis familiaris)
    - Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
      - Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
      - Polyubiquitination of substrate (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
        
        E3:Ub:substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
      - Release of E3 from polyubiquitinated substrate (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
      - Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
        
        E3:Ub:substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        RBX1:CUL3:BTB [cytosol] (Canis familiaris)
        
        BTB proteins [cytosol] (Canis familiaris)
        
        KLHL5 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RTS7

Gene Names

KLHL5

Reference Genes

ENSEMBL:ENSCAFG00845004801.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845004801.1 KLHL5

Other Identifiers

612886

Cfa.19492.1.A1_at

Cfa.19492.2.A1_at

Cfa.19724.1.S1_at

CfaAffx.24775.1.S1_s_at

CfaAffx.24779.1.S1_at

GO:0005515

GO:0016020

Participates

as a member of

BTB proteins [cytosol] (Canis familiaris)

Inferred From

KLHL5 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000109790

Ensembl

ENSCAFG00845004801, ENSCAFP00845006797, ENSCAFT00845008615

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