Reactome | PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CFA-8869104

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Q5U820

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:Q5U820

Reference Genes

BioGPS Gene:492302

ENSEMBL:ENSCAFG00000003429

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000003429

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030012224

KEGG Gene (Canis lupus familiaris):492302

Monarch:492302

NCBI Gene:492302

Reference Transcript

RefSeq:NM_001007143.1

Participates

as a member of

AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

Other forms of this molecule

PolyUb-CFTR [plasma membrane]

CFTR [lysosomal membrane]

CFTR [Golgi-associated vesicle membrane]

CFTR [endosome membrane]

PolyUb-CFTR [endosome membrane]

CFTR [plasma membrane]

misfolded CFTR [endoplasmic reticulum membrane]

Inferred From

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001007144.1

VGNC

39180

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