Reactome | VAMP7 [clathrin-coated endocytic vesicle membrane]

VAMP7 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CFA-8869135

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

VAMP7, A0A8I3S360

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S360

Gene Names

VAMP7

Reference Genes

BioGPS Gene:612663 VAMP7

ENSEMBL:ENSCAFG00845018278.1

Monarch:612663 VAMP7

NCBI Gene:612663 VAMP7

UCSC:A0A8I3S360 VAMP7

Reference Transcript

Other Identifiers

612663

Cfa.1744.1.A1_at

CfaAffx.30035.1.S1_at

CfaAffx.30037.1.S1_s_at

GO:0000139

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0006886

GO:0006887

GO:0006906

GO:0007041

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0030658

GO:0030659

GO:0030670

GO:0031410

GO:0031902

GO:0043005

GO:0045202

GO:0061024

GO:0098588

GO:0120025

Participates

as a component of

AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

Other forms of this molecule

VAMP7 [cytoplasmic vesicle membrane]

VAMP7 [Golgi membrane]

VAMP7 [lysosomal membrane]

VAMP7 [late endosome membrane]

VAMP7 [plasma membrane]

Inferred From

VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_038307261.1, XP_038444693.1, XP_038320616.1

ENSEMBL

ENSCAFT00845032329, ENSCAFP00845025271, ENSCAFG00845018278

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