Reactome | RAB5A [cytosol]

RAB5A [cytosol]

Stable Identifier

R-CFA-8870432

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

GGC-RAB5A, P18066

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - RAB geranylgeranylation (Canis familiaris)
    - RGGT geranylgeranylates RAB proteins (Canis familiaris)
      - CHMs:GGC-RABs:GDP [cytosol] (Canis familiaris)
        
        GGC-RABs:GDP [cytosol] (Canis familiaris)
        
        GGC-RABs [cytosol] (Canis familiaris)
        
        RAB5A [cytosol] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Rab regulation of trafficking (Canis familiaris)
    - RAB GEFs exchange GTP for GDP on RABs (Canis familiaris)
      - RAB5 GEFs exchange GTP for GDP on RAB5 (Canis familiaris)
        
        GGC-RAB5:GDP:GDIs,CHMs [cytosol] (Canis familiaris)
        
        GGC-RAB5:GDP [cytosol] (Canis familiaris)
        
        GGC-RAB5 [cytosol] (Canis familiaris)
        
        RAB5A [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:P18066

Gene Names

RAB5A

Reference Genes

BioGPS Gene:404008 RAB5A

ENSEMBL:ENSCAFG00000005814

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000005814 RAB5A

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030023727 RAB5A

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040022761 RAB5A

KEGG Gene (Canis lupus familiaris):404008 RAB5A

Monarch:404008 RAB5A

NCBI Gene:404008 RAB5A

Reference Transcript

RefSeq:NM_001003317.2 RAB5A

Other Identifiers

404008

Cfa.3879.1.S1_s_at

GO:0001726

GO:0003674

GO:0003924

GO:0005525

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005856

GO:0005886

GO:0006810

GO:0006897

GO:0007165

GO:0007267

GO:0008150

GO:0010008

GO:0015629

GO:0016192

GO:0019001

GO:0019003

GO:0022607

GO:0030139

GO:0031410

GO:0032009

GO:0036465

GO:0036477

GO:0039694

GO:0043167

GO:0043195

GO:0043226

GO:0043231

GO:0044403

GO:0045022

GO:0045121

GO:0045335

GO:0045921

GO:0051036

GO:0051489

GO:0098559

GO:0150093

GO:2000286

GO:2000300

Participates

as a member of

Other forms of this molecule

RAB5A [clathrin-coated endocytic vesicle membrane]

RAB5A [early endosome membrane]

RAB5A [endosome membrane]

RAB5A [cytosol]

Inferred From

GGC-RAB5A [cytosol] (Homo sapiens)

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 212 (in Homo sapiens)

Coordinate

212

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 213 (in Homo sapiens)

Coordinate

213

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_001003317.1

OpenTargets

ENSG00000144566

Ensembl

ENSCAFP00000008690, ENSCAFT00000009363, ENSCAFG00000005814

VGNC

45291

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.525	3