Reactome | GNAS [plasma membrane]

GNAS [plasma membrane]

Stable Identifier

R-CFA-8873941

Type

Set [CandidateSet]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

G alpha (s), Gs

Locations in the PathwayBrowser

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Hemostasis (Canis familiaris)

- Platelet homeostasis (Canis familiaris)
  - Prostacyclin signalling through prostacyclin receptor (Canis familiaris)
    - Gs activation by prostacyclin receptor (Canis familiaris)
      - Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Canis familiaris)
        
        G alpha (s):GTP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
      - Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)

Metabolism (Canis familiaris)

- Integration of energy metabolism (Canis familiaris)
  - Regulation of insulin secretion (Canis familiaris)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Canis familiaris)
      - GLP1R binds GLP1 (Canis familiaris)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
      - GLP1R binds GLP1R agonists (Canis familiaris)
        
        GLP1R:GLP1R agonists [plasma membrane] (Canis familiaris)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (s) signalling events (Canis familiaris)
      - GPER1 signaling (Canis familiaris)
        
        ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Canis familiaris)
        
        GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Canis familiaris)
        
        G alpha (s):GTP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
        
        GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Canis familiaris)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
        
        GPER:Heterotrimeric G-protein Gs binds ESTG (Canis familiaris)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
        
        GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Canis familiaris)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class B/2 (Secretin family receptors) (Canis familiaris)
      - Glucagon-type ligand receptors (Canis familiaris)
        
        GLP1R binds GLP1 (Canis familiaris)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)

Transport of small molecules (Canis familiaris)

- Aquaporin-mediated transport (Canis familiaris)
  - Vasopressin regulates renal water homeostasis via Aquaporins (Canis familiaris)
    - AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Canis familiaris)
      - AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Canis familiaris)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Canis familiaris)
        
        G alpha (s):GDP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)
      - AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Canis familiaris)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Canis familiaris)
        
        G alpha (s):GTP [plasma membrane] (Canis familiaris)
        
        GNAS [plasma membrane] (Canis familiaris)

Participants

candidates

GNAS [plasma membrane] (Canis familiaris)

Participates

as a component of

Inferred From

GNAS [plasma membrane] (Homo sapiens)

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