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CUL3 [cytosol]
Stable Identifier
R-CFA-8952516
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
G76-NEDD8-K712-CUL3, A0A8I3NYQ0
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
CUL3:RBX1 ubiquitinates KEAP1 (Canis familiaris)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Canis familiaris)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Canis familiaris)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
MAP1LC3B binds KEAP1 and SQSTM1 (Canis familiaris)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Canis familiaris)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Canis familiaris)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Canis familiaris)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
RBX1:CUL3 dissociates from forming autophagosome (Canis familiaris)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Canis familiaris)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Canis familiaris)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Canis familiaris)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CUL3:RBX1:BTB [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CUL3:RBX1:BTB [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
CUL3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NYQ0
Gene Names
CUL3
Reference Genes
ENSEMBL:ENSCAFG00845014725.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014725.1 CUL3
Other Identifiers
477392
Cfa.657.1.A1_s_at
CfaAffx.22384.1.S1_s_at
GO:0000122
GO:0000209
GO:0000278
GO:0000902
GO:0000910
GO:0000922
GO:0001701
GO:0001831
GO:0003824
GO:0004842
GO:0005112
GO:0005634
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005827
GO:0005856
GO:0005886
GO:0005929
GO:0006351
GO:0006355
GO:0006357
GO:0006511
GO:0006513
GO:0006888
GO:0006954
GO:0007010
GO:0007059
GO:0007080
GO:0007229
GO:0007369
GO:0010467
GO:0012501
GO:0016055
GO:0016192
GO:0016477
GO:0016567
GO:0016740
GO:0017145
GO:0023052
GO:0030154
GO:0030163
GO:0030332
GO:0031145
GO:0031208
GO:0031398
GO:0031461
GO:0031463
GO:0031625
GO:0031648
GO:0032467
GO:0032480
GO:0035024
GO:0036126
GO:0036211
GO:0040016
GO:0042802
GO:0043149
GO:0043161
GO:0043226
GO:0044346
GO:0045842
GO:0048208
GO:0048856
GO:0048870
GO:0051865
GO:0061024
GO:0061630
GO:0065003
GO:0070936
GO:0071230
GO:0071630
GO:0072576
GO:0072686
GO:0098794
GO:0098978
GO:0140014
GO:0140096
GO:0140252
GO:0160072
GO:1901992
GO:1904263
Participates
as a component of
NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
NEDD8-CUL3:RBX1:BTB [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
Other forms of this molecule
CUL3 [nucleoplasm]
CUL3 [cytosol]
Inferred From
G76-NEDD8-K712-CUL3 [cytosol]
(Homo sapiens)
Modified Residues
Name
neddylated lysine (monoNEDD8 [cytosol]) at 712 (in Homo sapiens)
Coordinate
712
Modification
monoNEDD8 [cytosol]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
OpenTargets
ENSG00000036257
Ensembl
ENSCAFG00845014725
,
ENSCAFP00845020783
,
ENSCAFT00845026365
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