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COMMD8 [cytosol]
Stable Identifier
R-CFA-8955107
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
COMMD8, A0A8I3N9G9
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
26S proteasome degrades HIFalpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
COMMDs:CCDC22 [cytosol] (Canis familiaris)
COMMDs [cytosol] (Canis familiaris)
COMMD8 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N9G9
Gene Names
COMMD8
Reference Genes
BioGPS Gene:475138 COMMD8
ENSEMBL:ENSCAFG00845008641.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008641.1 COMMD8
KEGG Gene (Canis lupus familiaris):475138 COMMD8
Monarch:475138 COMMD8
NCBI Gene:475138 COMMD8
Reference Transcript
RefSeq:XM_532368.5 COMMD8
Other Identifiers
475138
Cfa.1670.1.S1_at
Cfa.1670.2.S1_a_at
CfaAffx.3765.1.S1_s_at
GO:0005634
GO:0005654
GO:0005829
GO:0043226
Participates
as a candidate of
COMMDs [cytosol] (Canis familiaris)
Other forms of this molecule
COMMD8 [nucleoplasm]
Inferred From
COMMD8 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_532368.2
OpenTargets
ENSG00000169019
Ensembl
ENSCAFG00845008641
,
ENSCAFP00845011801
,
ENSCAFT00845015198
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