Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-GAB2 [cytosol]
Stable Identifier
R-CFA-912529
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-Y-GAB2, A0A8I3N9M7
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Phosphorylation of GAB2 by SFKs (Canis familiaris)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
phospho-GAB2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N9M7
Gene Names
GAB2
Reference Genes
ENSEMBL:ENSCAFG00845007967.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845007967.1 GAB2
Other Identifiers
485167
CfaAffx.8128.1.S1_s_at
GO:0005068
GO:0005737
GO:0005886
GO:0007169
GO:0008284
GO:0023052
GO:0030154
GO:0030316
GO:0048856
GO:0060090
Participates
as a component of
GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
Other forms of this molecule
phospho-GAB2 [cytosol]
phospho-GAB2 [cytosol]
GAB2 [cytosol]
phospho-GAB2 [cytosol]
Inferred From
p-Y-GAB2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000033327
Ensembl
ENSCAFT00845014019
,
ENSCAFP00845010867
,
ENSCAFG00845007967
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text