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TRAF3 [cytosol]
Stable Identifier
R-CFA-936402
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
K63polyUb-TRAF3, A0A8I3NRP3
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Canis familiaris)
Auto-ubiquitination of TRAF3 (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Canis familiaris)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Canis familiaris)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Canis familiaris)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Canis familiaris)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Canis familiaris)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Canis familiaris)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Canis familiaris)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
OPTN binds TBK1 within the activated TLR4 complex (Canis familiaris)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Canis familiaris)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)
K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TBK1 is phosphorylated within the activated TLR4 complex (Canis familiaris)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Canis familiaris)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAF3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NRP3
Gene Names
TRAF3
Reference Genes
ENSEMBL:ENSCAFG00845016806.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016806.1 TRAF3
Reference Transcript
RefSeq:XM_849522.4 TRAF3
Other Identifiers
490867
CfaAffx.27697.1.S1_s_at
GO:0001817
GO:0002224
GO:0002376
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005739
GO:0005768
GO:0005886
GO:0006351
GO:0006355
GO:0007165
GO:0008063
GO:0008270
GO:0009898
GO:0012501
GO:0016740
GO:0019901
GO:0019903
GO:0023052
GO:0030162
GO:0031410
GO:0031625
GO:0031996
GO:0032088
GO:0032481
GO:0032648
GO:0033209
GO:0035631
GO:0036211
GO:0042802
GO:0042981
GO:0043226
GO:0045087
GO:0050688
GO:0061630
GO:0098542
GO:0140096
Participates
as a component of
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
Other forms of this molecule
TRAF3 [cytosol]
TRAF3 [cytosol]
Inferred From
K63polyUb-TRAF3 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_854615.1
OpenTargets
ENSG00000131323
Ensembl
ENSCAFT00845029810
,
ENSCAFG00845016806
,
ENSCAFP00845023412
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