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K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
Stable Identifier
R-CFA-936965
Type
Complex
Species
Canis familiaris
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Canis familiaris)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Canis familiaris)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
Activation of TAK1 complex bound to activated TLR4 complex (Canis familiaris)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
Phosphorylated TAK1 leaves activated TLR receptor complex (Canis familiaris)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Canis familiaris)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Canis familiaris)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Canis familiaris)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Canis familiaris)
TRAF6 [cytosol]
(Canis familiaris)
Participates
as a member of
K63-linked polyUb TRAF6 complexes [endosome membrane] (Canis familiaris)
as an input of
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Canis familiaris)
as an output of
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Canis familiaris)
as a component of
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Canis familiaris)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Canis familiaris)
Inferred From
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Homo sapiens)
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