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PSME4 [cytosol]
Stable Identifier
R-CFA-947606
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PSME4, A0A8I3N952
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
Autodegradation of the E3 ubiquitin ligase COP1 (Canis familiaris)
Proteasome mediated degradation of COP1 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
p53-Independent G1/S DNA damage checkpoint (Canis familiaris)
p53-Independent DNA Damage Response (Canis familiaris)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Separation of Sister Chromatids (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Canis familiaris)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
The role of GTSE1 in G2/M progression after G2 checkpoint (Canis familiaris)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Canis familiaris)
Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of Securin (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Canis familiaris)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Canis familiaris)
Degradation multiubiquitinated Cyclin A (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Ubiquitin-dependent degradation of Cyclin D (Canis familiaris)
Proteasome mediated degradation of Cyclin D1 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
26S proteasome degrades Ub-NFE2L2 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
DNA Replication (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing-Cross presentation (Canis familiaris)
Cross-presentation of soluble exogenous antigens (endosomes) (Canis familiaris)
Proteasomal clevage of exogenous antigen (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Proteasomal cleavage of substrate (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Ubiquitinated IkB is degraded (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
26Sproteasome degrades K48polyUb-NIK (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of polyamines (Canis familiaris)
Regulation of ornithine decarboxylase (ODC) (Canis familiaris)
26S proteosome degrades ODC holoenzyme complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Metabolism of RNA (Canis familiaris)
Regulation of mRNA stability by proteins that bind AU-rich elements (Canis familiaris)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Canis familiaris)
AUF1:mRNA complex is destroyed (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
UCH proteinases (Canis familiaris)
ADRM1 binds 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
ADRM1:26S proteasome:UCHL5 [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
ADRM1:26S proteaseome binds USP14 (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
ADRM1:26S proteasome:USP14 [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Neddylation (Canis familiaris)
26S proteasome degrades HIFalpha (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
26S proteasome degrades Ub-NFE2L2 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
Proteasome degrades polyubiquitinated PTEN (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
Regulation of RAS by GAPs (Canis familiaris)
NF1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
MAPK6/MAPK4 signaling (Canis familiaris)
MAPK6 is degraded by the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'off' state (Canis familiaris)
Degradation of GLI1 by the proteasome (Canis familiaris)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
GLI3 is processed to GLI3R by the proteasome (Canis familiaris)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Hedgehog 'on' state (Canis familiaris)
ub-GLI is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
PCP/CE pathway (Canis familiaris)
Asymmetric localization of PCP proteins (Canis familiaris)
PRICKLE1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Degradation of beta-catenin by the destruction complex (Canis familiaris)
Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Degradation of AXIN (Canis familiaris)
Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Degradation of DVL (Canis familiaris)
Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
PSME4 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N952
Gene Names
PSME4
Reference Genes
ENSEMBL:ENSCAFG00845008342.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008342.1 PSME4
Other Identifiers
474594
Cfa.20009.1.S1_s_at
Cfa.552.1.A1_at
CfaAffx.4992.1.S1_s_at
GO:0005634
GO:0005654
GO:0005829
GO:0006281
GO:0006325
GO:0006974
GO:0010499
GO:0016504
GO:0022414
GO:0030154
GO:0030163
GO:0035092
GO:0042393
GO:0043226
GO:0048856
GO:0070577
GO:0070628
GO:0098772
GO:1990111
Participates
as a component of
26S proteasome [cytosol] (Canis familiaris)
Inferred From
PSME4 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000068878
Ensembl
ENSCAFG00845008342
,
ENSCAFT00845014984
,
ENSCAFP00845011620
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