Reactome | MCHR2 [plasma membrane]

MCHR2 [plasma membrane]

Stable Identifier

R-CFA-947674

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

MCHR2, A0A8I3N125

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        GPCRs that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Peptide ligand-binding receptors (Canis familiaris)
        
        Melanin-concentrating hormone receptors bind MCH (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Canis familiaris)
        
        MCHR1,MCHR2 [plasma membrane] (Canis familiaris)
        
        MCHR2 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N125

Gene Names

MCHR2

Reference Genes

ENSEMBL:ENSCAFG00845005808.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845005808.1 MCHR2

Reference Transcript

Other Identifiers

403562

Cfa.79.1.S1_s_at

CfaAffx.6229.1.S1_at

GO:0004930

GO:0007186

GO:0016020

GO:0023052

GO:0060089

Participates

as a member of

MCHR1,MCHR2 [plasma membrane] (Canis familiaris)

Inferred From

MCHR2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_013973495.1, XP_013973496.1

OpenTargets

ENSG00000152034

Ensembl

ENSCAFG00845005808, ENSCAFT00845010275, ENSCAFP00845008003

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