Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
Stable Identifier
R-CFA-9624425
Type
Complex
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
PTK2 autophosphorylates downstream of EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
PTK2 binds activated EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR autophosphorylation (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGFR downregulation (Canis familiaris)
Binding of CBL to EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
CBL ubiquitinates Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Localization of CBL:GRB2 to the membrane (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGFR interacts with phospholipase C-gamma (Canis familiaris)
Active PLC-gamma1 dissociates from EGFR (Canis familiaris)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
GAB1 signalosome (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Dephosphorylation of PAG by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
GAB1 phosphorylation by EGFR kinase (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
GRB2 events in EGFR signaling (Canis familiaris)
GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
Phosphorylation of EGFR by SRC kinase (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
SHC1 events in EGFR signaling (Canis familiaris)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
EGF-like ligands [extracellular region]
(Canis familiaris)
x 2
phospho-EGFR [plasma membrane]
(Canis familiaris)
Participates
as a component of
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
as an input of
PTK2 binds activated EGFR (Canis familiaris)
Binding of CBL to EGFR (Canis familiaris)
Localization of CBL:GRB2 to the membrane (Canis familiaris)
GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)
Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)
GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)
as an output of
Active PLC-gamma1 dissociates from EGFR (Canis familiaris)
EGFR autophosphorylation (Canis familiaris)
Phosphorylation of EGFR by SRC kinase (Canis familiaris)
Inferred From
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Homo sapiens)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text