Reactome | EREG [clathrin-coated endocytic vesicle membrane]

EREG [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CFA-9628816

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

EREG(60-108), A0A8I3N0H9

Locations in the PathwayBrowser

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Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EREG [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N0H9

Gene Names

EREG

Reference Genes

ENSEMBL:ENSCAFG00845006658.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006658.1 EREG

Other Identifiers

611946

CfaAffx.5548.1.S1_at

GO:0000278

GO:0001819

GO:0002376

GO:0005154

GO:0005576

GO:0005615

GO:0006260

GO:0006351

GO:0006355

GO:0007173

GO:0007267

GO:0008284

GO:0008285

GO:0009299

GO:0016071

GO:0019221

GO:0023052

GO:0030154

GO:0030297

GO:0032755

GO:0038134

GO:0038135

GO:0038138

GO:0042327

GO:0043616

GO:0045089

GO:0045740

GO:0045840

GO:0045892

GO:0048018

GO:0048146

GO:0048856

GO:0051151

GO:0098542

GO:0098772

GO:0140014

Participates

as a member of

EGF-like ligands [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

Other forms of this molecule

EREG [extracellular region]

Inferred From

EREG(60-108) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000124882

Ensembl

ENSCAFG00845006658, ENSCAFP00845009216, ENSCAFT00845011812

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