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OPTN [cytosol]
Stable Identifier
R-CFA-9687907
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
OPTN, A0A8I3MA34
Locations in the PathwayBrowser
Expand all
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Mitophagy (Canis familiaris)
PINK1-PRKN Mediated Mitophagy (Canis familiaris)
OPTN, TBK1 bind ubiquitinated MOM proteins (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Canis familiaris)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
p-S-TBK1 phosphorylates OPTN (Canis familiaris)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Canis familiaris)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Canis familiaris)
OPTN binds TBK1 within the activated TLR4 complex (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
TBK1 is phosphorylated within the activated TLR4 complex (Canis familiaris)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
OPTN binds CASP8 (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
OPTN:CASP8 [cytosol] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
OPTN [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MA34
Gene Names
OPTN
Reference Genes
ENSEMBL:ENSCAFG00845000154.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845000154.1 OPTN
Other Identifiers
478003
Cfa.15381.1.S1_at
Cfa.18676.1.S1_s_at
CfaAffx.8092.1.S1_s_at
GO:0001920
GO:0005737
GO:0005768
GO:0005773
GO:0005776
GO:0005794
GO:0005802
GO:0005829
GO:0006914
GO:0007005
GO:0007030
GO:0008104
GO:0010508
GO:0016192
GO:0023052
GO:0030674
GO:0031410
GO:0031593
GO:0034067
GO:0034620
GO:0042802
GO:0043001
GO:0043124
GO:0043226
GO:0046872
GO:0048471
GO:0050829
GO:0055037
GO:0060090
GO:0061734
GO:0070530
GO:0072659
GO:0090161
GO:0098542
GO:1904417
Participates
as an input of
OPTN binds CASP8 (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
OPTN binds TBK1 within the activated TLR4 complex (Canis familiaris)
OPTN, TBK1 bind ubiquitinated MOM proteins (Canis familiaris)
as a component of
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
OPTN:CASP8 [cytosol] (Canis familiaris)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Canis familiaris)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Canis familiaris)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Canis familiaris)
Other forms of this molecule
OPTN [recycling endosome membrane]
phospho-OPTN [nucleoplasm]
phospho-OPTN [cytosol]
OPTN [Golgi membrane]
phospho-OPTN [cytosol]
Inferred From
OPTN [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000123240
Ensembl
ENSCAFT00845000247
,
ENSCAFP00845000178
,
ENSCAFG00845000154
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